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The Cancer in Pregnancy ForumArchived Questions and Answers
This Forum has been the centre of an exceptional exchange of knowledge diagnosis, treatment, symptoms and other effects of cancer during pregnancy and lactation. All are welcome to review the Questions and Answers posted here, provided that they acknowledge and accept the important proviso and disclaimer below.
Dear all, a woman of 29 years old, 16 weeks pregnant, multigravida but nullipara, is just recently diagnosed diffuse large B-cell non-Hodgkin Lymphomia. Research for staging has to be conducted. Proposed chemo-treatment is CHOP. Woman feels OK, no signs of NHL like sweat, no enlargement of lymph nodes, bloodresults look normal. Please advise on a) staging procedure, especially risk of CT-scan of thorax/abdomen on fetus, b) risk of using CHOP during pregnancy and c) your idea on optimum timing of administering chemo during pregnancy (delay treatment or start immediately). Thanx!
In planning ct scan for staging, pay careful attention that the fetal dose (dose to uterus) does not exceed 5 rad. None of the chemotherapeutic agents have been shown to cause major malformations beyond the first trimester. Depending on the overall assessment of invasiveness and progress of the tumor, if delay may worsen the prognosis of mom, full therapy should start witout delay.