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The Cancer in Pregnancy ForumArchived Questions and Answers
This Forum has been the centre of an exceptional exchange of knowledge diagnosis, treatment, symptoms and other effects of cancer during pregnancy and lactation. All are welcome to review the Questions and Answers posted here, provided that they acknowledge and accept the important proviso and disclaimer below.
I have a male patient 31 years, successfully treated for AML with 3 treatment cycles of Ara-C and in remission 6 years. Patient was not advised of sperm storage options at the time of diagnosis, and now wishes to father children. I have been unable to find any information regarding male fertility following treatment with this drug. Do you know of any studies or anecdotal evidence of pregnancy after treatment with Ara-C? I was unable to find anything on MedLine. If the couple is successful in acheiving pregnancy, is there an increased risk of birth defect?
There have been anecdotal reports of male fertility even following bone marrow transplantation, which would include higher doses of chemotherapy than treatment for AML. If the couple is successful in achieving pregnancy, there have been no reports in the medical literature suggesting an increased risk for malformation.