• Home
  • Pregnancy &           
Breastfeeding
  • Bookshop
  • Contact us
  • Donate now
  • Frequently Asked Questions
  • Please read

Our Helplines

1-877-327-4636 Alcohol and Substance
1-800-436-8477 Morning Sickness
1-888-246-5840 HIV and HIV Treatment
1-877-439-2744 Motherisk Helpline
416-813-6780 Motherisk Helpline

Pharmacokinetics and Drug Metabolism

Understanding how drugs move through the body and cross the placenta is important in understanding their effects on the pregnancy or fetus. In this section we include studies and review articles that investigate the mechanisms by which drugs transfer across the human placenta and how they affect the fetus.

Fetal Drug Therapy

Motherisk Research


Placental Perfusion

Motherisk Research

  • J Pharmacol Exp Ther. 2000 Jul;294(1):141-6.
    Pastrakuljic A, Derewlany LO, Knie B, Koren G: The effects of cocaine and nicotine on amino acid transport across the human placental cotyledon perfused in vitro.
  • Pediatr Res. 2000 Mar;47(3):309-15.
    Challis DE, Pfarrer CD, Ritchie JW, Koren G, Adamson SL: Glucose metabolism is elevated and vascular resistance and maternofetal transfer is normal in perfused placental cotyledons from severely growth-restricted fetuses.
  • Life Sci. 1999;65(22):2359-71.
    Kopecky EA, Simone C, Knie B, Koren G: Transfer of morphine across the human placenta and its interaction with naloxone.
  • Life Sci. 1998;63(26):2333-42.
    Pastrakuljic A, Schwartz R, Simone C, Derewlany LO, Knie B, Koren G: Transplacental transfer and biotransformation studies of nicotine in the human placental cotyledon perfused in vitro.
  • Reprod Toxicol. 1998 Sep-Oct;12(5):517-23.
    Bailey B, Morris P, McMartin KI, Klein J, Duhart HM, Gillam MP, Binienda Z, Slikker W, Paule MG, Koren G: Transplacental pharmacokinetics of cocaine and benzoylecgonine in plasma and hair of rhesus monkeys.
  • 58/5 (PL-63-PL-66) 1996
    Simone C, Byrne BM, Derewlany LO, Koren G: Cocaine inhibits hCG secretion by the human term placental cotyledon perfused in vitro Life Science.

  • Simone C, Koren G: Cocaine clearance by the human placenta perfused in vitro Res-Commun-Alcohol-Subst-Abuse. 17/3-4 (125-134) 1996
  • Reproductive Toxicology. 11(2-3):215-9, 1997 Mar-Jun.
    Simone C, Byrne BM, Derewlany LO, Oskamp M, Koren G: The transfer, of cocaethylene across the human term placental cotyledonperfused in vitro.
  • Clin Perinatol 21: 463-481, 1994.
    Simone C, Derewlany LO, Koren G: Drug transfer across the placenta. Considerations in treatment and research
  • Ther Drug Monitor 14: 197-202, 1992.
    Klein J, Fernandes D, Pastuszak A, Koren G: Therapeutic drug monitoring of retinoids.
  • Med Pediatr Oncol 23: 476-479, 1994.
    Zemlickis D, Klein J, Moselhy G, Koren G: Cisplatin protein binding in pregnancy and the neonatal period.
  • Lab Clin Med Vol. 123, 3: 400-406, 1994.
    Simone C, Derewlany LO, Knie B, Kalow W, Koren G: Acetylcholinesterase and butyrylcholinesterase activity in the human placenta: Implications for fetal cocaine exposure
  • Perinatol Clinics N Amer 21: 463-481, 1994.
    Simone C, Derewlany LO, Koren G: Drug transfer across the placenta: Considerations in treatment and research

  • Simone CV, Derewlany LO, Knie B, Klein J, Koren G: Transplacental pharmacokinetics of cocaine; perfusion experiments with the human placenta. Am J Obst Gynecol (In Press).
  • Lab Clin Med Vol. 269, 2: 756-760, 1994.
    Derewlany LO, Knie B, Koren G: Arylamine-N-Acetyltransferase activity of the human placenta
  • J Pharmacol Exp Ther Vol. 269, 2: 761-765, 1994.
    Derewlany LO, Knie B, Koren G: Human Placental transfer and metabolism of p-aminobenzoic acid.
  • J Pharmacol Exp Ther 124: 134-141, 1994.
    Derewlany LO, Koren G: Biotransformation of carcinogenic arylamines and arylamides by human placenta.
  • Koren G, Klein J, Bologa-Campeanu M: Developmental pharmacology of aminogycosides and vancomycin. In: Drug Toxicity and Metabolism in Pediatrics (Kacew S, ed.). CRC Uniscience, Boca Raton, Fl. pp 173-184, 1990.
    In Book:
  • J Pharmacol Exp Ther 257: 735-740, 1991.
    Bologa M, Tang B, Klein J, Tesoro A, Giesbrecht E, Koren G: Pregnancy-induced changes in drug metabolism in epileptic women.

Pregnancy and Breastfeeding Resources
Valid XHTML 1.0 Transitional [Valid RSS]

* - "MOTHERISK - Treating the mother - Protecting the unborn" is an official mark of The Hospital for Sick Children. All rights reserved.

The information on this website is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and before you take any medications.

Copyright © 1999-2013 The Hospital for Sick Children (SickKids). All rights reserved.

The Hospital for Sick Children (SickKids) is a health-care, teaching and research centre dedicated exclusively to children; affiliated with the University of Toronto. For general inquires please call: 416-813-1500.

  |  Contact SickKids  |  Terms of Use