Pharmacokinetics and Drug Metabolism

Understanding how drugs move through the body and cross the placenta is important in understanding their effects on the pregnancy or fetus. In this section we include studies and review articles that investigate the mechanisms by which drugs transfer across the human placenta and how they affect the fetus.

Fetal Drug Therapy

Motherisk Research

• Am J Obstet Gynecol. 2000 Aug;183(2):424-30.
  Kopecky EA, Ryan ML, Barrett JF, Seaward PG, Ryan G, Koren G, Amankwah K: Fetal response to maternally administered morphine.

Placental Perfusion

Motherisk Research

• J Pharmacol Exp Ther. 2000 Jul;294(1):141-6.
  Pastrakuljic A, Derewlany LO, Knie B, Koren G: The effects of cocaine and nicotine on amino acid transport across the human placental cotyledon perfused in vitro.
• Pediatr Res. 2000 Mar;47(3):309-15.
  Challis DE, Pfarrer CD, Ritchie JW, Koren G, Adamson SL: Glucose metabolism is elevated and vascular resistance and maternofetal transfer is normal in perfused placental cotyledons from severely growth-restricted fetuses.
• Life Sci. 1999;65(22):2359-71.
  Kopecky EA, Simone C, Knie B, Koren G: Transfer of morphine across the human placenta and its interaction with naloxone.
• Life Sci. 1998;63(26):2333-42.
  Pastrakuljic A, Schwartz R, Simone C, Derewlany LO, Knie B, Koren G: Transplacental transfer and biotransformation studies of nicotine in the human placental cotyledon perfused in vitro.
• Reprod Toxicol. 1998 Sep-Oct;12(5):517-23.
  Bailey B, Morris P, McMartin KI, Klein J, Duhart HM, Gillam MP, Binienda Z, Slikker W, Paule MG, Koren G: Transplacental pharmacokinetics of cocaine and benzoylecgonine in plasma and hair of rhesus monkeys.
• 58/5 (PL-63-PL-66) 1996
  Simone C, Byrne BM, Derewlany LO, Koren G: Cocaine inhibits hCG secretion by the human term placental cotyledon perfused in vitro Life Science.
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  Simone C, Koren G: Cocaine clearance by the human placenta perfused in vitro Res-Commun-Alcohol-Subst-Abuse. 17/3-4 (125-134) 1996
• Reproductive Toxicology. 11(2-3):215-9, 1997 Mar-Jun.
  Simone C, Byrne BM, Derewlany LO, Oskamp M, Koren G: The transfer, of cocaethylene across the human term placental cotyledonperfused in vitro.
• Clin Perinatol 21: 463-481, 1994.
  Simone C, Derewlany LO, Koren G: Drug transfer across the placenta. Considerations in treatment and research
• Ther Drug Monitor 14: 197-202, 1992.
  Klein J, Fernandes D, Pastuszak A, Koren G: Therapeutic drug monitoring of retinoids.
• Med Pediatr Oncol 23: 476-479, 1994.
  Zemlickis D, Klein J, Moselhy G, Koren G: Cisplatin protein binding in pregnancy and the neonatal period.
• Lab Clin Med Vol. 123, 3: 400-406, 1994.
  Simone C, Derewlany LO, Knie B, Kalow W, Koren G: Acetylcholinesterase and butyrylcholinesterase activity in the human placenta: Implications for fetal cocaine exposure
• Perinatol Clinics N Amer 21: 463-481, 1994.
  Simone C, Derewlany LO, Koren G: Drug transfer across the placenta: Considerations in treatment and research
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  Simone CV, Derewlany LO, Knie B, Klein J, Koren G: Transplacental pharmacokinetics of cocaine; perfusion experiments with the human placenta. Am J Obst Gynecol (In Press).
• Lab Clin Med Vol. 269, 2: 756-760, 1994.
  Derewlany LO, Knie B, Koren G: Arylamine-N-Acetyltransferase activity of the human placenta
• J Pharmacol Exp Ther Vol. 269, 2: 761-765, 1994.
  Derewlany LO, Knie B, Koren G: Human Placental transfer and metabolism of p-aminobenzoic acid.
• J Pharmacol Exp Ther 124: 134-141, 1994.
  Derewlany LO, Koren G: Biotransformation of carcinogenic arylamines and arylamides by human placenta.
• Koren G, Klein J, Bologa-Campeanu M: Developmental pharmacology of aminogycosides and vancomycin. In: Drug Toxicity and Metabolism in Pediatrics (Kacew S, ed.). CRC Uniscience, Boca Raton, Fl. pp 173-184, 1990.
  In Book:
• J Pharmacol Exp Ther 257: 735-740, 1991.
  Bologa M, Tang B, Klein J, Tesoro A, Giesbrecht E, Koren G: Pregnancy-induced changes in drug metabolism in epileptic women.