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Retinoids in Clinical Practice ; The Risk-Benefit Ratio

(G. Koren, Ed). Marcel Dekker, NY 1993.

edited by Gideon Koren. Marcel Dekker, Inc. 1993.

A review of the elements involved in the risk-benefit ratio of retinoids, a unique and potent group of pharmacological agents. Written to help clinicians, ethicists, scientists, the pharmaceutical industry and regulatory agencies understand the complexities underlying the risk-benefit ratio of unique but highly teratogenic drugs.

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Contents: Introduction Preface Contributor		iii v ix
1.	Therapeutic Efficacy of Retinoids J.A.J. Kovacs and Neil H. Shear	1
2.	Vitamin A in the Fetus and Newborn Rafael Gorodischer	37
3.	Developmental Toxicology of Retinoids Narsingh D. Agnish and Devendra M. Kochhar	47
4.	Retinoid Embryopathy in Humans Franz W. Rosa	77
5.	Neural and Behavioral Pathology Following PrenatalExposure to Retinoids Jane Adams	111
6.	Clinical Relevance of Retinoid Parmacokinetics Julia Klein, Anne L. Pastuszak and Gideon Koren	129
7.	The Retinoid Pregnancy Prevention Program Anne L . Pastuszak and Gideon Koren	147
8.	Analysis of Contraception Failure in Canadian Women Treated with Systemic Retinoids Anne L. Pastuszak and Gideon Koren	177
9.	A New Approach to Counseling Women on Their Teratogenic Risk Gideon Koren	201
10.	Retinoid Embryopathy: Epidemiological Perspectives Donald L. Kaiser	209
11.	Regulatory Evolution: Approach to the Marketing of a Known Teratogen, Isotretinoin (Accutane) Michèle Brill-Edwards and Celia Viets	225
12.	Adverse Nonreproductive Effects of Retinoids in Humans J.A.J. Kovacs and Neil H. Shear	241
13.	Isotretinoin Benefits and Risks: Assessment of the Ratio Gideon Koren	261
index		267

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