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Low-molecular weight Heparins (Dalteparin)

Low-molecular-weight heparins during pregnancy

Ariel Many, MD Gideon Koren, MD, FRCPC

February 2005

ABSTRACT

QUESTION

A few years ago I suffered from pulmonary emboli. My physician recommended I use dalteparin during this pregnancy although, during my previous pregnancy, I had received subcutaneous heparin injections three times daily. Is dalteparin the same as heparin?

ANSWER

Based on the best available evidence from mostly small prospective case series, retrospective reports, and placental perfusion studies, low-molecular-weight heparins (LMWHs), such as dalteparin, are a safe and convenient alternative to heparin during pregnancy for both mothers and fetuses.

QUESTION

J'ai subi, il y a quelques années, une embolie pulmonaire. Mon médecin m'a recommandé d'utiliser de la daltéparine durant ma présente grossesse alors qu'au cours de la précédente, on m'administrait des injections sous-cutanées d'héparine trois fois par jour. La daltéparine est-elle le même médicament que l'héparine?

RÉPONSE

En se fondant sur les meilleures données scientifiques disponibles, tirées principalement d'études de séries de cas prospectives, de rapports rétrospectifs et d'études de la perfusion placentaire, les héparines à bas poids moléculaire (HBM) comme la daltéparine sont une alternative sûre et pratique à l'héparine pendant la grossesse, tant pour la mère que pour le foetus.

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