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Proton Pump Inhibitors

Use of proton pump inhibitors during pregnancy and breastfeeding

Alejandro A. Nava-Ocampo, MD, Elvia Y. Velazquez-Armenta, MSC, Jung-Yeol Han, MD, Gideon Koren, MD, FRCPC,

July 2006



A 36-year-old pregnant patient has symptoms of peptic disease. Treatment with diet and lifestyle modifications and also antacids has given her little relief. If she were not pregnant, I would prescribe a proton pump inhibitor (PPI) for her. She is now 4 weeks pregnant, and I need to determine whether PPIs are safe during pregnancy.


Data currently available suggest that omeprazole is not teratogenic in humans. While information on other PPIs is limited, a systematic review of the evidence suggests that they are also not teratogenic.


Une patiente enceinte âgée de 36 ans présente des symptômes de maladie peptique. Le traitement par des changements dans l’alimentation et le mode de vie ainsi que l’administration d’antiacides l’ont très peu soulagée. Si elle n’était pas enceinte, je lui prescrirais l’inhibiteur de pompe à protons (IPP). Elle en est à quatre semaines de gestation et je dois déterminer si les IPP sont sans danger durant la grossesse.


Les données actuellement accessibles indiquent que l’oméprazole n’est pas tératogène chez l’humain. Même si les renseignements sur d’autres IPP sont limités, une synthèse critique des données scientifiques fait valoir qu’ils ne sont pas tératogènes non plus.

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