• Home
  • Pregnancy &
Breastfeeding
  • Bookshop
  • Contact us
  • Donate now
  • Frequently Asked Questions
  • Please read

Our Helplines

1-877-327-4636 Alcohol and Substance
1-800-436-8477 Morning Sickness
1-888-246-5840 HIV and HIV Treatment
1-877-439-2744 Motherisk Helpline
416-813-6780 Motherisk Helpline

Trimethoprim-Sulfonamide Combination Therapy

Urinary tract infections in pregnancy

Monica Lee, RPh, Pina Bozzo, Adrienne Einarson, RN and Gideon Koren, MD FRCPC

June 2008

ABSTRACT

QUESTION

My pregnant patients often present with urinary tract infections. Are the medications commonly used for the management of urinary tract infections safe to use during pregnancy?

ANSWER

Existing data indicate that exposure to penicillins, cephalosporins, fluoroquinolones, nitrofurantoin, or phenazopyridine during pregnancy is not associated with increased risk of fetal malformations. Trimethoprim-sulfamethoxazole should be avoided, if possible, during the first trimester of pregnancy because of the antifolate effect associated with neural tube defects.

QUESTION

Il arrive souvent que mes patientes enceintes présentent une infection des voies urinaires. Les médicaments utilisés couramment pour la prise en charge des infections des voies urinaires sont-ils sans risque durant la grossesse?

RÉPONSE

Les données les plus récentes indiquent que l’exposition à la pénicilline, à la céphalosporine, au fluoroquinolone, à la nitrofurantoïne ou à la phénazopyridine durant la grossesse n’est pas associée à un risque accru de malformations fœtales. Il faudrait éviter dans la mesure du possible le triméthoprime-sulfaméthoxazole durant le premier trimestre en raison de son effet qui est de contrer l’acide folique, associé à des anomalies du tube neural.

[full story]
Valid XHTML 1.0 Transitional [Valid RSS]

* - "MOTHERISK - Treating the mother - Protecting the unborn" is an official mark of The Hospital for Sick Children. All rights reserved.

The information on this website is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and before you take any medications.

Copyright © 1999-2013 The Hospital for Sick Children (SickKids). All rights reserved.

The Hospital for Sick Children (SickKids) is a health-care, teaching and research centre dedicated exclusively to children; affiliated with the University of Toronto. For general inquires please call: 416-813-1500.

  |  Contact SickKids  |  Terms of Use