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The Motherisk Nausea and Vomiting of Pregnancy (NVP) Forum

Motherisk receives questions from around the world about morning sickness symptoms, effects, treatments and ways to cope. Those questions and answers are posted here for anyone to read, provided the reader acknowledges and accepts the proviso and disclaimer below.

Doxylamine Succinate

NVP Counselor
Date: 2004-06-10

Is doxylamine succinate 25 mg. safe for nausea & vomiting in pregnancy?

Doxylamine succinate 25 mg per day is safe. In fact it is one of the ingredients of Diclectin - the drug of choice for NVP in Canada. It will not increase your baseline risk of 1% to 3% for major malformation. To be effective, you might even need to take it in a larger dose. But talk to you doctor about that. As discussed in previous Questions and Answers in this Forum, in countries where Diclectin is not available, doxylamine is sometimes taken at 12.5 mg, three times per day.

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