1-877-439-2744 Motherisk Helpline
1-800-436-8477 Morning Sickness
1-877-327-4636 Alcohol and Substance
1-866-937-7678 Exercise in Pregnancy
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416-813-6780 Motherisk Helpline
Pregnancy & Breastfeeding Resources
Current Studies at Motherisk
The Safety of Diclectin in Breastfeeding
Neurodevelopment of Children Exposed in-Utero to Chemotherapy for Maternal Breast Cancer (Dr. I Nulman)
Diclegis Surveillance Program Study
Diclectin Surveillance Program Study
Study seeks women between 4 and 12 weeks in their pregnancy with morning sickness (NVP)
Pregnancy in Women with Multiple Sclerosis
Alcohol Use during Pregnancy
Lamisil in Pregnancy
Meridia in Pregnancy
Autoimmune Diseases in Pregnancy Project
The Motherisk Nausea and Vomiting of Pregnancy (NVP) ForumMotherisk receives questions from around the world about morning sickness symptoms, effects, treatments and ways to cope. Those questions and answers are posted here for anyone to read, provided the reader acknowledges and accepts the proviso and disclaimer below.
Our doctor told us to take Unisom and B6. What are the side effects to this medcine while pregnant? We are 10 weeks along and she is sick everyday. The doctor also prescribed Zofran, what are the side effects for this? Tks,
Unisom and Vitamin B6, the two components of Diclectin, the medication used in Canada for the treatment of NVP, have been used for over 40 years. They are the first, safe, recommended line of treatment. How to take B6/Unisom in countries where Diclectin is not available, is described in previous Questions and Answers in this Forum. If this treatment is not effective, (possibly because it was not started at the onset of symptoms while they were still mild), other treatments are listed in our treatment algorithm.
Zofran came to our attention about 6 years ago. Until our Motherisk study, published this month in the British Journal of Obstetrics and Gynecology, only 15 cases had been followed after birth. Our study of 176 women who called our Helpline showed 6 babies born with birth defects. Three of those were cases of hypospadias - not severe and common in that it affects 1 out of 3 male babies. These statistics (6 out of 176) fall within the 1 percent to 3 percent baseline risk for birth defect present in any pregnancy.