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The Motherisk Nausea and Vomiting of Pregnancy (NVP) Forum

Motherisk receives questions from around the world about morning sickness symptoms, effects, treatments and ways to cope. Those questions and answers are posted here for anyone to read, provided the reader acknowledges and accepts the proviso and disclaimer below.

Studying Zofran

Date: 2001-02-19

I am the mother of a 2 year old, and am considering getting pregnant again in the near future. I had hyperemesis (severe NVP) throughout my first pregnancy, and required IV fluids for 2 mos. I was treated with Zofran, and that finally stopped the vomiting after a few weeks. Are there any studies showing risk factors in using Zofran in the first trimester? Have any newer medications been tried in the past few years? Also, I have seen studies indicating that the presence of h.pylori has also been linked to morning sickness. Can you comment on how this is impacting your treatment of NVP? Thank you!

We're so glad you asked about Zofran. Motherisk has just started a study to investigate the safety and efficacy of Zofran (ondansetron) during pregnancy. Since it is a prospective study, only women who are currently pregnant and have used or are using the drug to treat nausea and vomiting are eligible to enroll. Participation involves an initial interview and another follow-up interview 4 to 6 months after the baby is born. The interviews are conducted over the phone, are strictly confidential and take approximately 20 minutes to complete. For more information about this study or other medications for NVP, please call our NVP counsellor. The call is free: 1-800-436-8477.

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